Noni Extract Superior To Chemotherapy for Lung Cancer (Preclinical Study)

Tragically, 1.4 million die from lung cancer each year, with 1.6 million newly diagnosed. Could the humble noni leaf extract offer a more effective cancer treatment than a drug that can cost over 100,000 dollars, and improves lung cancer survival rates by only a few months?
A promising new study published in the journal Food & Function titled, “Morinda citrifolia edible leaf extract enhanced immune response against lung cancer,” has found that an alcohol-based leaf extract of the noni tree (Morinda Citrifolia) was more effective than a commonly used chemotherapy drug in treating lung cancer in an animal model

In the new study, a team of Malaysian researchers tested the relative effectiveness of the drug erlotinib (trade name Tarceva), a so-called epidemal growth factor receptor inhibitor (EGFR inhibitor), to a noni leaf extract, in lung tumor-induced albino house mice (BALB/c), and found that 21 days of treatment with a 300 mg kg-1 body weight of leaf extract was more effective suppressing lung tumour growth than a 50 mg kg-1 body weight erlotinib treatment.

Remarkably, the noni leaf extract was observed to positively modulate a wide range of biological pathways, without discernable adverse effects:
* Increasing blood lymphocyte counts
* Increasing spleen tissue B cells
* Increasing T cells
* Increasing natural killer cells
* Reduced epidemal growth factor receptor (EGFR)
* Suppressed cyclooxgenase 2 (COX2) inflammatory markers
* Enhanced the tumor suppressor gene (phosphatase and tensin homolog, PTEN)
* Inhibited the tumour growth cellular genes transformed mouse 3T3 cell double minute 2 (MDM2) and V-raf-leukemia viral oncogene 1 (RAF1)
* Inhibited the mechanistic target of rapamycin (MTOR)) mRNA expression in the tumors.

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