A promising new study published in the journal Food & Function titled, “Morinda citrifolia edible leaf extract enhanced immune response against lung cancer,” has found that an alcohol-based leaf extract of the noni tree (Morinda Citrifolia) was more effective than a commonly used chemotherapy drug in treating lung cancer in an animal model
In the new study, a team of Malaysian researchers tested the relative effectiveness of the drug erlotinib (trade name Tarceva), a so-called epidemal growth factor receptor inhibitor (EGFR inhibitor), to a noni leaf extract, in lung tumor-induced albino house mice (BALB/c), and found that 21 days of treatment with a 300 mg kg-1 body weight of leaf extract was more effective suppressing lung tumour growth than a 50 mg kg-1 body weight erlotinib treatment.
Remarkably, the noni leaf extract was observed to positively modulate a wide range of biological pathways, without discernable adverse effects:
* Increasing blood lymphocyte counts
* Increasing spleen tissue B cells
* Increasing T cells
* Increasing natural killer cells
* Reduced epidemal growth factor receptor (EGFR)
* Suppressed cyclooxgenase 2 (COX2) inflammatory markers
* Enhanced the tumor suppressor gene (phosphatase and tensin homolog, PTEN)
* Inhibited the tumour growth cellular genes transformed mouse 3T3 cell double minute 2 (MDM2) and V-raf-leukemia viral oncogene 1 (RAF1)
* Inhibited the mechanistic target of rapamycin (MTOR)) mRNA expression in the tumors.